Reference:Shou Y, Le Z, Cheng HS, et al. Mechano-activated cell therapy for accelerated diabetic wound healing. Advanced Materials. 2023:2304638. doi: 10.1002/adma.202304638 A 2019 systematic review states that aloe vera and its compounds could improve wound healing. Overall evidence suggests it might be effective for wound healing of first and second degree burns. The review also indicates that aloe vera could help retain skin moisture and integrity while easing inflammation and preventing ulcers. Increase the oxygen concentration in blood in the wound area and shortens the wound healing process Within the first few days no significant difference in angiogenesis score was observed amongst the groups (Fig. ​ (Fig.6a1-a4, 6a1-a4, 6d). However, AM and AM+AV gel treated skin were shown to have appearance of more neo-vascularization (Fig. ​ (Fig.6a5-a20) 6a5-a20) with time. On the 12th day post burning, all treated groups appeared to have induced neo-epithelialization, in contrast to the control (Fig. ​ (Fig.6a5-a8, 6a5-a8, 6b). At day 18, neo-epithelization was clearly visible with incomplete epidermal and dermal layer (Fig. ​ (Fig.6a9-a12, 6a9-a12, 6b). Evaluation of wound closure, measurement of wound contraction and re-epithelialization. a Macroscopic wound healing images of Wistar rats at day 0, 6, 12, 18, 24 and 30 which were treated with AM, AV, AM+AV gel or without any gel (control). bClinical evaluation of wound healing regarding wound contraction in rats at day 6, 12, 18, 24 (b1) and (b2) (level of significant was set * P<0.05, ** P<0.01 and *** P<0.001). c Epithelialization period in different groups (*P<0.05, ** P<0.01 and *** P<0.001)

AgNPs release showed rapid antibacterial activity and simultaneous deferoxamine release promoted angiogenesis by enhancing the expression of hypoxia-inducible factor-1 alpha (HIF-1α) and VEGF

The team of researchers are furthering their research to finetune the effectiveness of the magnetic wound-healing gel and are testing the gel’s effectiveness on the tissue of people with diabetes. Wound healing, especially in the field of diabetic foot ulcers, has always been a challenging arena. Diabetic foot patients do not heal as well as normal patients and their healing journey is often prolonged,” said Assistant Professor Francis Wong Keng Lin, Consultant,Department of Orthopaedic Surgery, Sengkang General Hospital. Researchers have recently developed a healing gel for people with diabetes that treats diabetic wounds faster, stops them from returning and prevents amputations. Each treatment involves the application of a bandage pre-loaded with a hydrogel containing skin cells for healing and magnetic particles. To maximise therapeutic results, a wireless external magnetic device is used to activate skin cells and accelerate the wound healing process. The ideal duration of magnetic stimulation is about one to two hours.

The inflammatory phase is characterized by hemostasis, chemotaxis, and increased vascular permeability, limiting further damage, closing the wound, removing cellular debris and bacteria, and fostering cellular migration. The duration of the inflammatory stage usually lasts several days. [2]Chronic wounds influence quality of life and present an economic burden because of prolonged treatment periods. The effects of various factors, such as pressure, ischemia, inflammation, and stress, can cause delayed healing. Different methods, such as debridement, hyperbaric oxygen therapy, ultrasound and electromagnetic therapy, negative pressure wound therapy, and skin grafts, have been used to treat chronic wounds. Each method exhibits its own advantages and disadvantages. Debridement significantly improves wound healing by shortening healing times. Hyperbaric oxygen therapy is expensive, and its use is limited to diabetic foot ulcers. Ultrasound and electromagnetic therapy can be used for venous and pressure ulcers and surgical incisions. However, these therapies might superficially damage or burn the endothelial tissues if proper parameters are not used. Negative pressure wound therapy limits patient mobility. In addition, excessive noise during treatment causes patient discomfort. Skin grafts are more expensive than other methods and require sophisticated procedures. All of the aforementioned techniques require clinical specialists with fully equipped health facilities. On extensive weeping or infected wounds, consult a doctor before using Savlon Scar Prevention Gel because other complementary treatments might be necessary. Honey has antioxidant, antibacterial, and anti-inflammatory properties. People have used the substance in traditional wound healing recipes for a long time. What our team has achieved is to identify a sweet spot by applying gentle mechanical stimulation,” said Asst Prof Tay. “The result is that the remaining skin cells get to ‘work-out’ to heal wounds, but not to the extent that it kills them.” While the magnetic wound-healing gel has shown great promise in improving diabetic wound healing, it could also revolutionise the treatment of other complex wound types.

Antibacterial hydrogels can also be developed by the modification of the polymers with antibacterial peptides or amphoteric compounds. These structures work similarly to the inorganic materials and chitosan as they induce physical damage to the bacterial membrane and inhibit bacterial proliferation [ 73, 74, 84]. Coconut oil contains the substance monolaurin, a fatty acid with antimicrobial properties. Fatty acids found in vegetable oils are assumed to play a large part in helping wounds heal. A person can use coconut oil on a wound to help reduce the risk of contracting an infection. There are hydrogels that possess intrinsic antibacterial properties. Chitosan, for example, is known to have inherent antibacterial activity. The electrostatic interaction between its polycationic structures with the negatively charged bacterial cell wall alters membrane permeability [ 92]. Upon destruction of the bacterial cell wall, the subsequent interaction of the chitosan with the bacterial intracellular components inhibits DNA replication. A 2016 review states that laboratory research suggests honey significantly improves the healing rate of wounds in animals. It also says that it reduced scar formation and inhibited bacterial growth in acute wounds and burns.Burns, hemostasis, tissue defects, regeneration of nerves, wound dressings, augmentation of soft tissue, artificial dermis skin replacement If a person wishes to try turmeric for a wound, they should limit usage to closed, minor wounds. An open injury would require medical-grade products with a doctor’s approval. matrix that enhances skin regeneration, decreases enzymatic degradation, provides structural support, and enhances cell proliferation by creating ECM like structure.

This environment stimulates the release of several growth factors including but not limited to vascular endothelial growth factor (VEGF) and basic fibroblast factor (bFF). These growth factors help to drive neovascularisation and angiogenesis within the wound. Initial proliferative phase (poor blood supply)Aloe vera is a plant belonging to the cactus family. It contains a substance that is rich in both vitamins and minerals. People often use OTC antibacterial ointments for minor wounds, but they may not be necessary. A person may use petroleum jelly, which acts as a barrier to protect the wound beyond a waterproof bandage. 2. Aloe vera Daily activity causes skin cells to undergo mechanical forces, however, it is recommended that people with diabetic wounds limit rigorous activity as it could kill the cells which are vital for healing. Representative microscopic images for HFF1 and HaCaT cell attachment and proliferation. a HFF1 cells (2h to 8h) and ( b) HaCaT cells (3h to 12h) attachment test. c Proliferation tests of HFF1 for 2, 4, and 6days. d The proliferation of HaCaT from day 3 to day 6 in media with and without gels Results from lad tests of the gel showed that, when coupled with magnetic stimulation, it healed diabetic wounds approximately 240 per cent faster by increasing the cells’ growth rate and more than doubles the amount of collagen produced, which is vital in the healing process.